File:The main markers of immunosenescence.jpg
The_main_markers_of_immunosenescence.jpg (797 × 413 pixels, file size: 70 KB, MIME type: image/jpeg)
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Italiano: The main markers of immunosenescence. The main feature of immunosenescence is the degeneration of the thymus, which is accompanied by a decrease in IL-7 secretion. Senescence is accompanied by a decrease in telomere length and telomerase activity. Senescence T cells show reduced SA-β-galactosidase activity, cytotoxic activity, expression of functional molecules such as IFN-γ, scarce proliferation, and also arrested cell cycle, due to an increase of the related proteins, P16 and P21. During the remodeling of the immune system with age, changes in immune cell markers are mainly characterized by the loss of CD27 and CD28 expression and the increase in CD57 and KLRG-1 expression. During aging, glycolysis and ROS production are increased, while mitochondrial synthesis is decreased |
| Date | |
| Source | Lian, Jingyao (2020-11-10). "Immunosenescence: a key player in cancer development". Journal of hematology & oncology 13 (1). Springer Science and Business Media LLC. DOI:10.1186/s13045-020-00986-z. PMID 33168037. PMC: 7653700. ISSN 1756-8722. |
| Author |
Jingyao Lian 1 2, Ying Yue 1 2 3, Weina Yu 1 2, Yi Zhang 4 5 1-Biotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou, 450052, Henan, China. 2-State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou, 450052, Henan, China. 3-Clinical Laboratory, Henan Medical College Hospital Workers, Zhengzhou, 450000, Henan, China. 4-Biotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou, 450052, Henan, China. yizhang@zzu.edu.cn. 5-State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou, 450052, Henan, China. yizhang@zzu.edu.cn. |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 14:54, 14 June 2021 | | 797 × 413 (70 KB) | OppidumNissenae (talk | contribs) | Uploaded a work by Jingyao Lian 1 2, Ying Yue 1 2 3, Weina Yu 1 2, Yi Zhang 4 5 1-Biotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou, 450052, Henan, China. 2-State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou, 450052, Henan, China. 3-Clinical Laboratory, Henan Medical College Hospital Workers, Zhengzhou, 450000, Henan, China. 4-Biotherapy Center and Cancer Center, The First Affiliated Hospital... |
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