File:The epithelial-mesenchymal transition (EMT).jpg
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| Description | Figure 2.The epithelial-mesenchymal transition (EMT). The process of EMT requires loss of cell-cell contact, apical-basal polarity, and adhesion molecules (e.g., E-cadherin). Transformed epithelial cells then gain front-rear polarity and dissociate from the neighboring cells with increased expressions of mesenchymal markers. Thus, EMT increases cell motility which facilitates invasion and metastasis during cancer progression. Hypoxia is one of the driving forces that facilitate EMT. During hypoxia, many transcriptional regulators that govern the expressions of E-cadherin are activated by HIF-1α. As a result, downregulation of E-cadherin facilitates the development of mesenchymal phenotypes, leading to invasion and metastasis. |
| Date | |
| Source | https://www.researchgate.net/publication/293042602_Hypoxia_Epithelial-Mesenchymal_Transition_and_TET-Mediated_Epigenetic_Changes Hypoxia, Epithelial-Mesenchymal Transition, and TET-Mediated Epigenetic Changes Journal of Clinical Medicine February 20165(2):24 DOI:10.3390/jcm5020024 |
| Author | Shih-Han Kao, Kou-Juey Wu and Wen-Hwa Lee |
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© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
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| current | 17:44, 20 May 2024 | | 1,432 × 513 (532 KB) | Rasbak (talk | contribs) | {{Information |description=Figure 2.The epithelial-mesenchymal transition (EMT). The process of EMT requires loss of cell-cell contact, apical-basal polarity, and adhesion molecules (e.g., E-cadherin). Transformed epithelial cells then gain front-rear polarity and dissociate from the neighboring cells with increased expressions of mesenchymal markers. Thus, EMT increases cell motility which facilitates invasion and metastasis during cancer progression. Hypoxia is one of the driving forces tha... |
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