File:The beneficial effect of PF4 on cognition is neurogenesis-dependent.webp
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From the study "Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice"
Summary
[edit]DescriptionThe beneficial effect of PF4 on cognition is neurogenesis-dependent.webp |
English: "a Experimental design of aged DCXDTR mice receiving intravenous (i.v.) PF4 injections every third day for 24 days and subsequent testing in the active place avoidance (APA) task, with an additional 4 injections of diphtheria toxin (DT) beginning on day 18. b The number of DCX+ cells following DT treatment and APA testing. c PF4-treated mice (blue) improved during the APA task, whereas this effect was absent in all other groups, including when PF4-treated mice received injections of DT, specifically ablating adult neurogenesis. d PF4-treated mice showed a reduction in the number of entries into the shock zone, whereas mice in the other three groups did not improve. Improvements following PF4 treatment were observed in all parameters of the test, including the number of shocks received (e), entries into the shock zone per distance travelled (f), and time to first (g) and second (h) entrance into the shock zone, as well as the maximum time spent avoiding the shock zone (i). Saline n = 11 mice; Saline DT n = 9 mice; PF4 n = 12 mice; PF4 DT n = 12 mice. Bars represent mean ± SEM. Statistical analysis was performed using one-way ANOVAs with Sidak post hoc comparison to compare groups on day 5 and two-way repeated measures ANOVAs with Dunnett’s post hoc comparison to compare groups throughout the 5-day test. ANOVA result *p < 0.05, **p < 0.01, ***p < 0.001, Dunnett’s comparison Saline vs. PF4 #p < 0.05, PF4 vs. PF4 DT +p < 0.05. Source data are provided as Source Data file." |
Date | |
Source | https://www.nature.com/articles/s41467-023-39873-9 |
Author | Authors of the study: Odette Leiter, David Brici, Stephen J. Fletcher, Xuan Ling Hilary Yong, Jocelyn Widagdo, Nicholas Matigian, Adam B. Schroer, Gregor Bieri, Daniel G. Blackmore, Perry F. Bartlett, Victor Anggono, Saul A. Villeda & Tara L. Walker |
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current | 18:05, 17 November 2023 | ![]() | 2,000 × 2,332 (273 KB) | Prototyperspective (talk | contribs) | Uploaded a work by Authors of the study: Odette Leiter, David Brici, Stephen J. Fletcher, Xuan Ling Hilary Yong, Jocelyn Widagdo, Nicholas Matigian, Adam B. Schroer, Gregor Bieri, Daniel G. Blackmore, Perry F. Bartlett, Victor Anggono, Saul A. Villeda & Tara L. Walker from https://www.nature.com/articles/s41467-023-39873-9 with UploadWizard |
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