File:The Journal of laboratory and clinical medicine (1915) (14772565992).jpg

Identifier: journaloflaborat07cent (find matches)
Title: The Journal of laboratory and clinical medicine
Year: 1915 (1910s)
Authors: Central Society for Clinical Research (U.S.)
Subjects: Biological Assay Diagnosis, Laboratory Disease Medicine Medicine Research
Publisher: St. Louis, C. V. Mosby
Contributing Library: Gerstein - University of Toronto
Digitizing Sponsor: University of Toronto

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sweet almond oil on the intestine of a cat. that, since the hydrolysis of the benzyl esters injected into the dogs bloodstream proceeded very slowly, an addition of alkali in this manner wouldstart the hydrolysis and bring about a reaction on the intestinal organ similarto that which would result from oral administration of these esters. We pro-ceeded, therefore, (Fig. 8) by injecting 1 c.c. of n/10 NaOH in 95 per centalcohol into the vein of a dog prepared for this experiment, and recordedmarked intestinal contractions. This was followed by an injection of 1 c.c. ofa 20 per cent solution of benzyl acetylsalicylate in n/10 alcoholic NaOH. Thisproduced a marked intestinal relaxation. After a considerable lapse of time(approximately an hour and a half) the same experiment was repeated sub-stituting benzyl fumarate for benzyl acetylsalicylate (Fig. 9). The recordsshoM that the benzyl acetylsalicylate, which contains only slightly more than THE JOURNAL OF LABORATORY AND CLINICAL MEDICINE
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PHARMACOLOGY OF BEXZYI. COMPOUNDS 77 half as much beuzyl as the same dose of benzyl fumarate, produced a moremarked and more lasting intestinal relaxation in the same dog. Fig. 10 shows the result of the intravenous injection of a 20 per centsolution of benzyl acetylsalicylate in n/10 sodium hydroxide, prepared ap-proximately half an hour prior to the injection. The reaction was almost im-mediate and very marked. Similar experiments were made with benzyl benzoate (Fig. 11). An intra-venous injection was made into a dog, of 12 c.c. of benzyl benzoate, undiluted.As usual, there was hardly any reaction on the dogs intestine from this in-jection. This was now followed by 12 c.c. of benzyl benzoate dissolved in

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