File:The Journal of laboratory and clinical medicine (1915) (14770543394).jpg

Identifier: journaloflaborat07cent (find matches)
Title: The Journal of laboratory and clinical medicine
Year: 1915 (1910s)
Authors: Central Society for Clinical Research (U.S.)
Subjects: Biological Assay Diagnosis, Laboratory Disease Medicine Medicine Research
Publisher: St. Louis, C. V. Mosby
Contributing Library: Gerstein - University of Toronto
Digitizing Sponsor: University of Toronto

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74 THE JOURNAL OF LABORATORY AND CLINICAL MEDICINE
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En PHARMACOLOGY OF BENZYL COMPOUNDS 75 injection of benzyl acetylsalicylate in this instance were undoubtedly due toa partial asphyxia induced by stoppage of respiration. As the respiration Avasreestablished, it will be noted that the intestinal relaxation continued. Con-trol experiments were carried out to show any possible influence of sweet al-mond oil (Fig. 7). This oil had only a negligible effect—if any—upon themovements of the intestine, while 1 c.c. of a 20 per cent benzyl fumaratesolution in sweet almond oil produced a distinct relaxation of the intestine inthe same cat. This striking difference in response to intravenous benzyl esterinjections between the dog and the cat led us to search for a means of hasten-ing the hydrolysis and thereby the action of the benzyl esters in the dog. This was accomplished by dissolving the benzyl esters in alcoholic sodiumhydroxide, immediately prior to the injections (90 seconds). It was thought ^ -^fejiwcoi^^n- 4 Fig- 7.—Showing the c

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