File:The Journal of laboratory and clinical medicine (1915) (14769846701).jpg

Identifier: journaloflaborat07cent (find matches)
Title: The Journal of laboratory and clinical medicine
Year: 1915 (1910s)
Authors: Central Society for Clinical Research (U.S.)
Subjects: Biological Assay Diagnosis, Laboratory Disease Medicine Medicine Research
Publisher: St. Louis, C. V. Mosby
Contributing Library: Gerstein - University of Toronto
Digitizing Sponsor: University of Toronto

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enzyl esters we have inves-tigated. The rate of hydrolysis of the benzj-l group in benzyl acetylsalicylatedoes not exceed that of the salicylate (See Yolwiler and Vliet, Journal ofAmerican Chem. Soc, 1921, 43, 1672). Since their power to relax smoothmuscle of the intestine is greater than that of simple benzyl esters possessinga much higher rate of hydrolysis, it appears reasonably certain that thisgreater efficacy is due to their difference in structure from the simple benzylesters. This difference consists in the molecule of the salicylate containinga hydroxyl group and that of the acetylsalicylate, a substituted hydroxylgroup. Our records demonstrate, on the other hand, that these acids alonedo not possess any striking power to relax the intestine. It seems evident,therefore, that the action of these two benzyl esters is not the ensemble oftheir molecular constituents, but rather a more potent one possessed by theintact molecules. 584 THE JOURNAL OF LABORATORY AND CLINICAL MEDICINE
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PHARMACOLOGY OF BENZYL COMPOUNDS 585 In our investigation of benzyl esters of higher melting points (solid aboveroom temperature), we have used the Trendelenburg method,^ unless other-wise specified. The benzyl esters were dissolved in sweet almond oil in suchamounts that the various solutions used for injection contained the sameproportion of the benzyl radical. Thus, for instance, 0.87 gm. of benzylstearate dissolved in 4.13 gm. of oil correspond in benzyl content to a solu-tion of 0.35 gm. of benzyl fumarate in 4.65 gm. of oil. Fig. 7 presents a comparison between benzyl stearate and fumarate onthe intestine of a cat. It shows that benzyl fumarate produces a greater re-laxation than benzyl stearate when injected in less than half the amount byweight. Fig. 8 is a record taken by the Jackson method/ showing the rather X^^JU-vn ^tid^A

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