File:The Journal of laboratory and clinical medicine (1915) (14749897876).jpg

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Identifier: journaloflaborat07cent (find matches)
Title: The Journal of laboratory and clinical medicine
Year: 1915 (1910s)
Authors: Central Society for Clinical Research (U.S.)
Subjects: Biological Assay Diagnosis, Laboratory Disease Medicine Medicine Research
Publisher: St. Louis, C. V. Mosby
Contributing Library: Gerstein - University of Toronto
Digitizing Sponsor: University of Toronto

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Fig. 10.—For description see text. of benzyl acetylsalieylate was made in a quantity containing the same amountof benzyl as 1/2 c.cof benzyl benzoate, that is, 0.66 c.c. dissolved in 2-1/2 c.c.of n/4 alcoholic sodium hydroxide. The intestinal relaxation obtained from thisdose was very rapid and pronounced and stronger than that produced by the pro-portionate dose of benzyl benzoate. The record in this instance does not do fulljustice to the power of benzyl acetylsalieylate to relax the intestine, because therespiration ceased, and as a result of the asphyxia, the intestine started to PHARMACOLOGY OF BENZYL COMPOUNDS 79
Text Appearing After Image:
80 THE JOURNAL OF LABORATORY AXD CLIXICAL MEDICINE contract again too soon. It should be noted that the amounts of sodium hydrox-ide used in these experiments Avere only 1 10 to 1 4 of those required to hydro-lyze the total amounts of benzyl present in the injections. The experiments with alcoholic sodium hydrate were intended only tothrow further light upon the fate in the body and the manner of action of thebenzyl esters. The strikingly powerful action, upon intestinal muscles, of benzyl salicy-late and benzyl acetylsalicylate (Figs. 6. 8 and 14) led us to experiment furtherwith them. The salicylate, according to Volwiler and Vliet, hydrolyzes moresloAvly, in vitro, than any of the esters investigated by us. yet its power of re-laxing the intestine is so great as to be out of all proportions to its rate ofhydrolysis. The benzyl acetylsalicylate is still more powerful; in fact, it sur-passes all the esters investigated.

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https://www.flickr.com/photos/internetarchivebookimages/14749897876/

Author Central Society for Clinical Research (U.S.)
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Flickr tags
InfoField
  • bookid:journaloflaborat07cent
  • bookyear:1915
  • bookdecade:1910
  • bookcentury:1900
  • bookauthor:Central_Society_for_Clinical_Research__U_S__
  • booksubject:Biological_Assay
  • booksubject:Diagnosis__Laboratory
  • booksubject:Disease
  • booksubject:Medicine
  • booksubject:Research
  • bookpublisher:St__Louis__C__V__Mosby
  • bookcontributor:Gerstein___University_of_Toronto
  • booksponsor:University_of_Toronto
  • bookleafnumber:86
  • bookcollection:gerstein
  • bookcollection:toronto
  • bookcollection:medicalheritagelibrary
Flickr posted date
InfoField
29 July 2014



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