File:The Biochemical journal, 1907 (1907) (14780686001).jpg

Identifier: biochemicaljourn02bioc (find matches)
Title: The Biochemical journal, 1907
Year: 1907 (1900s)
Authors: Biochemical Society (Great Britain) University of Liverpool. Biochemical Dept
Subjects: Biochemistry
Publisher: London (etc.) Cambridge University Press
Contributing Library: Gerstein - University of Toronto
Digitizing Sponsor: University of Toronto

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this connexion, that Zutz (36), with a commercial specimenof Cornutin citrate, observed no rise of temperature in a guinea-pig, which, after aninjection of 10 mgms., recovered in ij hours. (2) Rabbit, 1410 grammes. 12.4 p.m. I mgm. of ergotoxine phosphate dissolved in 0*5 c.c. of distilled water injected into right ear-vein.12.12 p m. No symptoms except very rapid respiration and prominence of the eye-balls.1.10 p.m. Respiration still rapid. Jerky movements begin.2.0 p.m. Recovered. (3). Rabbit, 1420 grammes. 11.55 ^-n^- 2 mgms. ergotoxine, dissolved in I c.c. dilute NaOH, injected into rightear-vein, 2 mgms. similarly into left ear-vein. Altogether, therefore, 4 mgms. 11.58 a.m. Very rapid respiration and twitching of the limbs. 12.5 p.m. Fore-legs unable to support the animal, which sprawls with its nose on the ground. Persistent fine tremors and occasional twitching of the limbs.12.42 p.m. All legs extended. Dyspnoea continues. 12.56 p.m. Rectal temperature, 42° C. !**«VWptl«!aM
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Fig. 5 Rabbit, showing ears shortened by gangrene two months after injection of 4 mgms. of ergotoxine. ERGOTOXINE AND CONSTITUENTS OF ERGOT 257 From this lime, uiuil iccu\ery begins, animal lies with fore limbs spread wide andhind limbs extended. The latter are occasionally and alternately flexed and again ex-tended, producing a wobbling of the hinder part of the animal on the fore part, whichremains stationary, supported on the broad base formed by the chest and the spread forelimbs. The head is at first depressed, with nose un the table : later (2.30 p.m.) it israised. At 3.30 p.m. profuse salivation was noticed, saliva dropping from the mouthon to the floor. Respiratory sounds indicated bronchial secretion. About 5 p.m. recoverybegan. Animal could now draw up the hind legs and the dyspnoea was less severe. Nextmorning recovery was practically complete, and the animal remained apparently normalfor a fortnight. It was then noticed that the skin of the peripheral two-thirds of each ea

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