File:The American journal of roentgenology, radium therapy and nuclear medicine (1906) (14777443353).jpg

Identifier: americanjournroen08ameruoft (find matches)
Title: The American journal of roentgenology, radium therapy and nuclear medicine
Year: 1906 (1900s)
Authors: American Radium Society American Roentgen Ray Society
Subjects: Radiotherapy X-rays
Publisher: Springfield, Ill. C.C. Thomas
Contributing Library: Gerstein - University of Toronto
Digitizing Sponsor: University of Toronto

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E INFLUENCE OF X-RAY ORGAN STIMULATION ONTHE COAGULATION MECHANISM By clarence C. SAELHOF, M.D. Department of Pathology and Laboratory of Physiological Chemistry, University of Illinois, College of Medicine CHICAGO, ILLINOIS DURING the experimental observationson the effect of the x-ray exposure ofthe hepatic, splenic and intestinal areas forvarying periods of time as reported in thepreceding paper, evidence of a change in thecoagulation time of the blood was obtained.A number of recent investigators, observingthe reduction of the coagulation time follov^-ing the raying of the splenic area have sug- extensive loss of blood. The essential factorthat arrested and cured the hemorrhagic ten-dency was the increase in the quantity of thecoagulating ferment, and this was realizedby the action of the roentgen rays on thespleen. He thinks they exert a specific func-tional stimulus on the elements of the spleenother than the lymph follicles. The bloodplatelet count does not seem to be modified.
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Norniai normal — i -■ l i ■= l/2hr. 1 5 24 48 72 1/21. I 5 24 49 7-a V^ *^ J. 5 24 4e 73 Chart I. Coagulation Time of the Blood after A-Ray Exposltre egr Five, Ten and Twenty Minutes. gested that measure for therapeutic use incases of severe hemorrhage. Stephan ^ forinstance reports a case of purpura fulminansin a man of forty-five in which a refractoryhemorrhagic diathesis was successfully com-bated early in 1919 by means of deep roent-genotherapy applied to the spleen. Investiga-tions that he undertook in connection withthis result led him to state that roentgenradiation applied to the spleen rapidly de-creases the coagulation time of the blood invitro, and increases likewise to a consider-able extent the amount of coagulating fer-ment in the blood serum. Radiation seemsto have the same effect on the orranism as The coagulation time was shortened some-times to one fourth even in normal subjectsby raying the spleen; the maximum effectwas apparent between the second and fourthho

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