File:Testicular biopsy shows severely impaired spermatogenesis with an aspect of histological mosaicism. Human.png
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| Description | Figure 5. Testicular biopsy shows severely impaired spermatogenesis with an aspect of histological mosaicism. The seminiferous tubules were of overall reduced diameter (decreased by approximately 30%–50% compared to physiological adult pubertal seminiferous tubules of 150–250 µm in diameter) and lined by a thickened basal membrane. The seminiferous tubules were either atrophic (*), with Sertoli cells only (**), or presenting spermatogenesis arrest at the spermatocyte stage (•). The interstitial tissue was fibro-edematous with numerous Leydig cells (‡) (hematoxylin–eosin–saffron). Thick black arrow indicates Sertoli cells, thin black arrow indicates spermatocyte, and solid black triangle indicates spermatogonia. Biopsy fragments were fixed in alcohol, formalin, and acetic acid (AFA) and paraffin-embedded. Sections of 3 μm were stained by hematoxylin–phloxin–saffron. Slide evaluation was performed on a Leica DM2500 microscope. Two different scales: 300 µm (A) and 200 µm (B) |
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| Source | https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1171822/full Teoli J, Mallet D, Renault L, Gay C-L, Labrune E, Bretones P, Giscard D’Estaing S, Cuzin B, Dijoud F, Roucher-Boulez F and Plotton I (2023) Case Report: Longitudinal follow-up and testicular sperm extraction in a patient with a pathogenic NR5A1 (SF-1) frameshift variant: p.(Phe70Serfs*5). Front. Endocrinol. 14:1171822. doi: 10.3389/fendo.2023.1171822 |
| Author | Teoli J, Mallet D, Renault L, Gay C-L, Labrune E, Bretones P, Giscard D’Estaing S, Cuzin B, Dijoud F, Roucher-Boulez F and Plotton I |
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© 2023 Teoli, Mallet, Renault, Gay, Labrune, Bretones, Giscard D’Estaing, Cuzin, Dijoud, Roucher-Boulez and Plotton. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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| current | 17:50, 30 July 2024 | | 1,721 × 513 (1.54 MB) | Rasbak (talk | contribs) | |
| 17:44, 30 July 2024 |  | 850 × 249 (532 KB) | Rasbak (talk | contribs) | {{Information |description=Figure 5. Testicular biopsy shows severely impaired spermatogenesis with an aspect of histological mosaicism. The seminiferous tubules were of overall reduced diameter (decreased by approximately 30%–50% compared to physiological adult pubertal seminiferous tubules of 150–250 µm in diameter) and lined by a thickened basal membrane. The seminiferous tubules were either atrophic (*), with Sertoli cells only (**), or presenting spermatogenesis arrest at the spermatocyt... |
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