File:T.suis Immuno-modulatory mechanisms.png

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English: Cascade of immuno-molecular events hypothesized to lead to the modulation of immune response in Trichuris suis-infected humans. Molecules linked to the T-cell receptor and chemokine signalling pathways could be involved in the stimulation of the Th2-type immune response, which, in turn, stimulates the expansion of populations of pro-inflammatory cells and cytokines. T. suis homologues of secreted leukocyte protease inhibitors (SLPIs) could inhibit hyper-responsiveness of the immune system by down-regulating the activity of Th2-type cells.
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http://www.plosone.org/article/info:doi/10.1371/journal.pone.0023590

  • Cantacessi C, Young ND, Nejsum P, Jex AR, Campbell BE, et al. (2011) The Transcriptome of Trichuris suis – First Molecular Insights into a Parasite with Curative Properties for Key Immune Diseases of Humans. PLoS ONE 6(8): e23590. doi:10.1371/journal.pone.0023590
Author Cinzia Cantacessi, Neil D. Young, Peter Nejsum, Aaron R. Jex, Bronwyn E. Campbell, Ross S. Hall, Stig M. Thamsborg, Jean-Pierre Scheerlinck, Robin B. Gasser
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This file is licensed under the Creative Commons Attribution-Share Alike 2.5 Generic license.
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