File:Structure of Cdk2-cyclin A-p27.png
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Structure_of_Cdk2-cyclin_A-p27.png (454 × 401 pixels, file size: 130 KB, MIME type: image/png)
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Structure of Cdk2-cyclin A-p27
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[edit]DescriptionStructure of Cdk2-cyclin A-p27.png |
English: The structure of the Cdk2–cyclin A–p27 complex, as determined by X-ray crystallography, reveals that the inhibitor p27 (pink) stretches across the top of the cyclin–Cdk complex. Only the amino-terminal region of p27 is shown in the structure. The amino-terminal end of this fragment contains an RXL motif that interacts with the hydrophobic patch of cyclin A (blue). The carboxy-terminal end of the p27 fragment interacts extensively with the beta sheet of Cdk2 (green), causing extensive disruptions to its structure; p27 also inserts into the ATP-binding site of Cdk2 and directly inhibits ATP binding. (PDB 1jsu)[1] |
Date | |
Source | Own work |
Author | Rob Hurt |
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 01:00, 8 April 2020 | ![]() | 454 × 401 (130 KB) | Rob Hurt (talk | contribs) | Uploaded own work with UploadWizard |
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