File:Structure of Cdk2-cyclin A-p27.png

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Structure_of_Cdk2-cyclin_A-p27.png ‎(454 × 401 pixels, file size: 130 KB, MIME type: image/png)

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Structure of Cdk2-cyclin A-p27

Summary

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Description
English: The structure of the Cdk2–cyclin A–p27 complex, as determined by X-ray crystallography, reveals that the inhibitor p27 (pink) stretches across the top of the cyclin–Cdk complex. Only the amino-terminal region of p27 is shown in the structure. The amino-terminal end of this fragment contains an RXL motif that interacts with the hydrophobic patch of cyclin A (blue). The carboxy-terminal end of the p27 fragment interacts extensively with the beta sheet of Cdk2 (green), causing extensive disruptions to its structure; p27 also inserts into the ATP-binding site of Cdk2 and directly inhibits ATP binding. (PDB 1jsu)[1]
Date
Source Own work
Author Rob Hurt

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I, the copyright holder of this work, hereby publish it under the following license:
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Date/TimeThumbnailDimensionsUserComment
current01:00, 8 April 2020Thumbnail for version as of 01:00, 8 April 2020454 × 401 (130 KB)Rob Hurt (talk | contribs)Uploaded own work with UploadWizard

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