File:Structural domains of the HIV-1 integrase.jpg

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Structural_domains_of_the_HIV-1_integrase.jpg ‎(652 × 180 pixels, file size: 20 KB, MIME type: image/jpeg)

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English: Schematic of the domain structure of HIV integrase. Three structural and functional domains have been identified. The N-terminal domain (residues 1-50) contains a HHCC zinc finger motif and is required for dimerization and binding of cellular factors. The catalytic core domain (residues 51-212) contains the conserved residues forming a catalytic triad (D64, D116 and E152) that are required to coordinate essential divalent metal ions (Mn2+ or Mg2+). The C-terminal domain (residues 213-288) binds DNA non-specifically.
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Author Hopur3

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current16:18, 20 September 2011Thumbnail for version as of 16:18, 20 September 2011652 × 180 (20 KB)Hopur3 (talk | contribs)

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