File:Structural-Basis-and-Kinetics-of-Force-Induced-Conformational-Changes-of-an-αA-Domain-Containing-pone.0027946.s008.ogv
Structural-Basis-and-Kinetics-of-Force-Induced-Conformational-Changes-of-an-αA-Domain-Containing-pone.0027946.s008.ogv (Ogg Theora video file, length 23 s, 512 × 480 pixels, 9.15 Mbps, file size: 25.49 MB)
Captions
Summary
[edit]DescriptionStructural-Basis-and-Kinetics-of-Force-Induced-Conformational-Changes-of-an-αA-Domain-Containing-pone.0027946.s008.ogv |
English: SMD simulation of pulling the α7-helix of the LFA-1 αA domain. The simulated structures were shown in cyan with the α7-helix shown in green. The equilibrated α7-helix at the up (blue) and down (red) positions are superimposed for comparison. The Mg2+ ion is shown as golden spheres. A 250-pN force was applied to the Cα atom of the residue 308 at the C-terminal of the α7-helix. At 15 ns, the force was released to allow the system to relax. The Cα atoms of residues 131–135, 167–172, 177–181 and 232–234 of the β1–β4 strands were constrained to prevent the rigid body motion of the αA domain. The backbone hydrogen-bonding atoms in the α7-helix were constrained to prevent it from unfolding. |
||
Date | |||
Source | Video S1 from Xiang X, Lee C, Li T, Chen W, Lou J, Zhu C (2011). "Structural Basis and Kinetics of Force-Induced Conformational Changes of an αA Domain-Containing Integrin". PLOS ONE. DOI:10.1371/journal.pone.0027946. PMID 22140490. PMC: 3225382. | ||
Author | Xiang X, Lee C, Li T, Chen W, Lou J, Zhu C | ||
Permission (Reusing this file) |
|
||
Provenance InfoField |
|
File history
Click on a date/time to view the file as it appeared at that time.
Date/Time | Thumbnail | Dimensions | User | Comment | |
---|---|---|---|---|---|
current | 04:23, 15 November 2012 | 23 s, 512 × 480 (25.49 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.
Transcode status
Update transcode statusMetadata
This file contains additional information such as Exif metadata which may have been added by the digital camera, scanner, or software program used to create or digitize it. If the file has been modified from its original state, some details such as the timestamp may not fully reflect those of the original file. The timestamp is only as accurate as the clock in the camera, and it may be completely wrong.
Author | Xiang X, Lee C, Li T, Chen W, Lou J, Zhu C |
---|---|
Usage terms | http://creativecommons.org/licenses/by/3.0/ |
Image title | SMD simulation of pulling the ?7-helix of the LFA-1 ?A domain. The simulated structures were shown in cyan with the ?7-helix shown in green. The equilibrated ?7-helix at the up (blue) and down (red) positions are superimposed for comparison. The Mg2+ ion is shown as golden spheres. A 250-pN force was applied to the C? atom of the residue 308 at the C-terminal of the ?7-helix. At 15 ns, the force was released to allow the system to relax. The C? atoms of residues 131?135, 167?172, 177?181 and 232?234 of the ?1??4 strands were constrained to prevent the rigid body motion of the ?A domain. The backbone hydrogen-bonding atoms in the ?7-helix were constrained to prevent it from unfolding. |
Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2011 |
- Extracellular matrix
- Videos of protein structures
- Cell mechanics
- Biophysics theory
- Macromolecular structure analysis
- Biophysical simulations
- Molecular cell biology
- Cell adhesion
- Videos of biomechanics
- Intercellular adhesion molecule-1
- Lymphocyte function-associated antigen-1
- Molecular dynamics simulation
- Protein binding
- Videos of secondary protein structure
- Videos of tertiary protein structure
- Time factors
- Beta-Alanine
- Media from PLOS ONE