File:Small cell variant of squamous cell carcinoma mimicking small cell lung carcinoma - CK5 6 immunostain -Case 292 (14924383216).jpg

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This is a very instructive case of the small cell variant of squamous cell carcinoma (SCC) mimicking small cell lung carcinoma (SCLC) based not only on morphologic features but also on the results of immunostains. CD56 and CK5/6, the immunostains that were initially obtained were both positive. TTF 1, chromogranin A and synaptophysin were negative. A small percentage of squamous cell carcinomas may express CD56 and a small percentage of high grade neuroendocrine carcinomas may express CK5/6. p63 and p40 stains were subsequently obtained and both were positive confirming the diagnosis of SCC. AE1/AE3 was also positive but did not exhibit the dot like staining of the nuclear membranes that is often seen in SCLC. Careful examination of cell morphology at higher magnifications shows some cells with eosinophilic cytoplasm. Nuclear detail is lacking in these images.

Case contributed by Dr. Jian-Hua Qiao.
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Source Small cell variant of squamous cell carcinoma mimicking small cell lung carcinoma - CK5/6 immunostain -Case 292
Author Yale Rosen from USA

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This image was originally posted to Flickr by Pulmonary Pathology at https://flickr.com/photos/30950973@N03/14924383216 (archive). It was reviewed on 3 October 2019 by FlickreviewR 2 and was confirmed to be licensed under the terms of the cc-by-sa-2.0.

3 October 2019

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current07:22, 3 October 2019Thumbnail for version as of 07:22, 3 October 20192,048 × 1,542 (567 KB)Netha Hussain (talk | contribs)Transferred from Flickr via #flickr2commons

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