File:Schematics and pilot testing with increasing informational density (DishBrain playing Pong).jpg

English: "(A) Diagrammatic overview of DishBrain setup.

(B) Software components and data flow in the DishBrain closed-loop system. Voltage samples flow from the MEA to the “Pong” environment, and sensory information flows back to the MEA, forming a closed loop. Full caption in Figure S2. (C) Schematic showing the different phases of stimulation to the culture. In line with this is the corresponding summed activity on the raster plot over 100 seconds. The appearance of random stimulation after a ball missing versus system-wide predictable stimulation upon a successful hit is apparent across all three representations. Corresponding images on the right show the position of the ball on both x and y axis relative to the paddle and back wall in percentage of total distance shown on the same timescale. (D) Final electrode layout schematic for DishBrain Pong-world gameplay.

(E) ∗ = p < 0.05, ∗∗∗ = p < 0.001; error bars = 95% CI. Shows average rally length over three distinct experiment rounds during design of DishBrain Pong-world where each subsequent experiment provided higher density information on ball position than the previous. MCC tested over 272 sessions, n = 50 biological replicates; HCC tested over 579 sessions, n = 18 biological replicates."