File:Schematic diagram of the TGF-β signaling a.jpg
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| Description | Figure 2. Schematic diagram of the TGF-β signaling. (Left) The canonical (Smad) signaling involves the TGF-β-Receptor, which phosphorylates R-Smads (Smad2 and 3). Smad2/3 bind to Smad4, translocate to the nucleus and activate, among others, genes that directly regulate EMT. Smad7, negatively controls the TGF-β signaling by inhibiting R-Smads phosphorylation, by competing directly with Smad2 and 3 for the TGF-β-Receptor binding. (Right) The non-canonical (non-Smad) TGF-β signaling pathway starts from the TGF-β-Receptor and mediates the induction of EMT through the activation of several kinases |
| Date | |
| Source | https://www.frontiersin.org/articles/10.3389/fcell.2020.607483/full The Epithelial-to-Mesenchymal Transition as a Possible Therapeutic Target in Fibrotic Disorders. Front. Cell Dev. Biol. 8:607483. doi: 10.3389/fcell.2020.607483 |
| Author | Di Gregorio J, Robuffo I, Spalletta S, Giambuzzi G, De Iuliis V, Toniato E, Martinotti S, Conti P and Flati V |
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Copyright © 2020 Di Gregorio, Robuffo, Spalletta, Giambuzzi, De Iuliis, Toniato, Martinotti, Conti and Flati. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 17:18, 18 May 2024 | | 1,069 × 870 (537 KB) | Rasbak (talk | contribs) | {{Information |description=Figure 2. Schematic diagram of the TGF-β signaling. (Left) The canonical (Smad) signaling involves the TGF-β-Receptor, which phosphorylates R-Smads (Smad2 and 3). Smad2/3 bind to Smad4, translocate to the nucleus and activate, among others, genes that directly regulate EMT. Smad7, negatively controls the TGF-β signaling by inhibiting R-Smads phosphorylation, by competing directly with Smad2 and 3 for the TGF-β-Receptor binding. (Right) The non-canonical (non-Smad) T... |
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