File:Role of reactive oxygen species in development of cancer.png
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| Description | The role of reactive oxygen species (ROS) in the development of cancer. The increase in ROS in normal cells triggers stress responses and DNA repair to repair the ROS-mediated damage to genetic materials. However, the exposure to high levels of oxidants and the consequential redox imbalance lead to DNA damage, including base mismatch, single-strand break, or double-strand break. Moreover, ROS induce DNA mutations that could cause a loss of p53 function and DNA repair disfunction, leading to genomic instability, which further leads to the activation of oncogenes, aberrant metabolic stress, mitochondrial dysfunction, and a decrease in antioxidants. All these events activate a vicious cycle that amplifies oxidative stress and promotes cancer development. |
| Date | |
| Source | https://www.mdpi.com/2076-3921/11/9/1829 |
| Author | Rosalia Emma, Massimo Caruso, Davide Campagna, Roberta Pulvirenti, Giovanni Li Volti |
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| current | 16:13, 22 February 2024 | | 3,187 × 3,393 (508 KB) | Ameisenigel (talk | contribs) | {{Information |Description=The role of reactive oxygen species (ROS) in the development of cancer. The increase in ROS in normal cells triggers stress responses and DNA repair to repair the ROS-mediated damage to genetic materials. However, the exposure to high levels of oxidants and the consequential redox imbalance lead to DNA damage, including base mismatch, single-strand break, or double-strand break. Moreover, ROS induce DNA mutations that could cause a loss of p53 function and DNA repai... |
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