File:Role of Autophagy and primary cilia in embryonic stem cell lineage specification.png
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| Description | Figure 5. Role of Autophagy and primary cilia in embryonic stem cell lineage specification. Primary cilium promotes autophagosome formation in hESCs, keeping embryonic development in check via the controlled degradation of Nrf2. Inhibition of primary cilia formation results in increased levels of Nrf2 due to constrained autophagosome formation. Increased levels of Nrf2 reduce the expression of PAX6, neuroectoderm fate-determinant transcription factor, which in turn results in inhibition of hESC’s commitment to neuroectoderm lineage. Conversely, activation of primary cilia via serum starvation causes higher levels of PAX6 expression and promotes commitment to neuroectoderm lineage. Created with BioRender.com. |
| Date | |
| Source | https://www.mdpi.com/2073-4409/10/6/1428 https://doi.org/10.3390/cells10061428 Cilium Is Involved in Stem Cell Differentiation and Renewal through the Regulation of Multiple Signaling Pathways. Cells 2021, 10, 1428. |
| Author | Yanardag, S.; Pugacheva, E.N. Primary |
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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 13:48, 5 May 2024 | | 3,128 × 2,729 (815 KB) | Rasbak (talk | contribs) | {{Information |description=Figure 5. Role of Autophagy and primary cilia in embryonic stem cell lineage specification. Primary cilium promotes autophagosome formation in hESCs, keeping embryonic development in check via the controlled degradation of Nrf2. Inhibition of primary cilia formation results in increased levels of Nrf2 due to constrained autophagosome formation. Increased levels of Nrf2 reduce the expression of PAX6, neuroectoderm fate-determinant transcription factor, which in turn... |
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