File:Repressors modulate transcription output..jpg
From Wikimedia Commons, the free media repository
Jump to navigation
Jump to search
Repressors_modulate_transcription_output..jpg (552 × 346 pixels, file size: 51 KB, MIME type: image/jpeg)
File information
Structured data
Captions
Captions
Add a one-line explanation of what this file represents
DescriptionRepressors modulate transcription output..jpg |
English: A. Oct4, Nanog and Tcf3 co-occupy a common set of pluripotency-associated factors in ESCs. Whereas Oct4 and Nanog may activate genes required for pluripotency, Tcf3 behaves as a repressor that also binds these common genes, thereby controlling the overall gene expression levels. B. At the single gene level, the transcription output is partly determined by the combination of factors that activate or repress transcription. The well-characterized Oct4 gene cis-regulatory regulatory region is bound by several TFs that act as either activator or repressor. In the undifferentiated state, Oct4, Sox2, Nanog, Sall4 and LRH1 activate the promoter while Tcf3 and GCNF repress it. The balance of molecules acting on this critical gene controls the cell fate of either self-renewal or differentiation. |
Date | Published September 15, 2008. |
Source |
[1] Direct
|
Author | Tam, W.-L. and Lim, B., Genome-wide transcription factor localization and function in stem cells (September 15, 2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.19.1, http://www.stembook.org. |
Permission (Reusing this file) |
![]() ![]() This file is licensed under the Creative Commons Attribution 3.0 Unported license.
|
File history
Click on a date/time to view the file as it appeared at that time.
Date/Time | Thumbnail | Dimensions | User | Comment | |
---|---|---|---|---|---|
current | 18:59, 5 April 2013 | ![]() | 552 × 346 (51 KB) | Smallbot (talk | contribs) | Uploading CC-BY images from the the StemBook http://www.stembook.org/ 123/173 |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.
Structured data
Items portrayed in this file
depicts
Hidden categories: