File:Representative parametric PET images of 11C-(R)-PK11195 binding in CFS.ME patient (A) and healthy control (B).jpg
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| Description |
English: FIGURE 1. (A and B) Representative parametric PET images of 11C-(R)-PK11195 binding in CFS/ME patient (A) and healthy control (B). Anatomic locations were mapped on coronal MR images. (C) Mean (±SD) regional tissue time–activity curves of 11C-(R)(R)-PK11195 for region of interest in cerebellum and thalamus in CFS/ME group and HC group. Scale indicates BPND. AMY = amygdala; CC = cingulate cortex; HC = healthy control; HIP = hippocampus; MID = midbrain; THA = thalamus; and PON = pons.
[1]Image Data Analysis All 11C-(R)-PK11195 BPND images were normalized to the Montréal Neurologic Institute space, smoothed with an isotropic 8-mm gaussian kernel, and analyzed by Statistical Parametric Mapping 5 software (SPM5; Wellcome Department of Cognitive Neurology) using a categoric design. The between-group comparison (CFS/ME patients vs. healthy controls) of 11C-(R)-PK11195 BPND and correlation analysis of 11C-(R)-PK11195 BPND values and clinical scores were performed on a voxel-by-voxel basis using t statistics with the statistical threshold set at a P value of less than 0.005 at the voxel level and a P value of less than 0.05 with a correction for multiple comparisons at the cluster level for the entire brain (familywise error). The regions of interest for the cingulate cortex, hippocampus, amygdala, thalamus, midbrain, and pons were defined from the Wake Forest University PickAtlas (21) and applied to the smoothed images. Statistical Analyses Values are shown as mean ± SD unless stated otherwise. Symptom severity, blood-cytokine data, and regional 11C-(R)-PK11195 BPND values were compared across the groups using Student t tests. Categoric variables were compared across the groups using Fisher exact tests. The relation between symptom severity scores and 11C-(R)-PK11195 BPND values was analyzed using Pearson correlation in the CFS/ME group. All P values were 2-tailed, and values of less than 0.05 were considered to be statistically significant. Statistical analyses were performed using SPSS 20.0 software (SPSS). |
| Date | |
| Source | http://jnm.snmjournals.org/content/55/6/945.long |
| Author |
Yasuhito Nakatomi, Kei Mizuno, Akira Ishii, Yasuhiro Wada, Masaaki Tanaka, Shusaku Tazawa, Kayo Onoe, Sanae Fukuda, Joji Kawabe, Kazuhiro Takahashi, Yosky Kataoka, Susumu Shiomi, Kouzi Yamaguti, Masaaki Inaba, Hirohiko Kuratsune and Yasuyoshi Watanabe This research was originally published in JNM. Author(s). Title. J Nucl Med. 2014;vol:55-no.6 945-950. © SNMMI. |
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