File:Remdesivir 3D.png
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Remdesivir_3D.png (411 × 350 pixels, file size: 580 KB, MIME type: image/png)
Captions
Captions
A ball-and-stick model of the antiviral drug Remdesivir.
Summary
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| Description |
English: 3D molecular structure (Jmol) of remdesivir (RDV). RDV is an antiviral compound with a broad spectrum of antiviral activities (e.g. SARS-CoV and MERS-CoV) and currently being used in clinical trials against the novel coronavirus COVID-19 to test its clinical efficiacy. Chemical formula C27H35N6O8P. Legend: carbon atom grey; hydrogen, white; nitrogen, blue; oxygen, red; phosphorous, yellow. IUPAC name (2S)-2-{(2R,3S,4R,5R)-[5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]phenoxy-(S)-phosphorylamino}propionic acid 2-ethyl-butyl ester. The molecule contains several aromatic rings with delocalized π bonding.
RDV is a prodrug which is metabolized to the nucleoside analog GS-5734 that targets viral RNA polymerase. An effective nucleoside analog must evade proofreading (by 3′-5′ exoribonuclease) to successfully interfere with CoV RNA synthesis for better clinical efficiacy. |
| Date | |
| Source | Remdesivir 3D |
| Author | ChiralJon |
Licensing
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This file is licensed under the Creative Commons Attribution 2.0 Generic license.
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- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
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This image was originally posted to Flickr by ChiralJon at https://flickr.com/photos/69057297@N04/49624859732 (archive). It was reviewed on 7 March 2020 by FlickreviewR 2 and was confirmed to be licensed under the terms of the cc-by-2.0. |
File history
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 08:36, 13 March 2020 | | 411 × 350 (580 KB) | GlobalPhotos1 (talk | contribs) | Revised stereochemistry. |
| 12:21, 7 March 2020 |  | 424 × 388 (500 KB) | GlobalPhotos1 (talk | contribs) | Transferred from Flickr via #flickr2commons |
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