File:Relevant molecular pathways and targeted agents in TNBC.jpg
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[edit]DescriptionRelevant molecular pathways and targeted agents in TNBC.jpg |
English: Schematic of the most relevant molecular pathways and targeted agents in TNBC. Tyrosine kinase receptor is activated upon binding of growth factors leading to activation of signaling pathways. PI3K/AKT pathway and inhibitor drugs: Phosphorylated PI3K activate AKT. The activation of AKT triggers downstream protein complexes mTORC activation that initiate gene transcription and promote cell growth. AR pathway is activated in LAR subtype tumors. Platinum drugs act through DNA damaging mechanism. PARP inhibitors induce “synthetic lethality” in BRCA deficient tumors. |
Date | |
Source | https://www.mdpi.com/2072-6694/12/4/916 |
Author | Elena Vagia,Devalingam Mahalingam andMassimo Cristofanilli |
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current | 12:00, 18 March 2022 | 728 × 850 (138 KB) | Andrawaag (talk | contribs) | Uploaded a work by Elena Vagia,Devalingam Mahalingam andMassimo Cristofanilli from https://www.mdpi.com/2072-6694/12/4/916 with UploadWizard |
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