File:Reduced RA signaling promotes increased proliferation of neural precursors.jpg
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| Description | FIGURE 7. Reduced RA signaling promotes increased proliferation of neural precursors. Embryos (Xenopus) were injected in one blastomere at the 2-cell stage to affect only half of the embryo. Injections included cyp26a1 mRNA with FITC-dextran or FITC-dextran alone. At the onset of gastrulation, the embryos were sorted based on the injected side and further incubated until late gastrula. Embryos were stained by immunohistochemistry with antibodies against pHH3. The positive cells were counted on both sides of the midline, averaging 24 pHH3 positive cells on the control side in each embryo. (A) Control embryo injected with FITC-dextran on the right side. (B) Embryo injected with cyp26a1 mRNA + FITC-dextran on the left side. (C) Relative proliferation analysis based on the number of pHH3-positive cells on both sides. The distribution of all embryos analyzed is shown. The number of embryos analyzed is shown. ****, p < 0.0001 compared to the control (FITC-dextran) sample ratio. |
| Date | |
| Source | https://www.frontiersin.org/articles/10.3389/fcell.2023.1282273/full Alcohol induces neural tube defects by reducing retinoic acid signaling and promoting neural plate expansion. Front. Cell Dev. Biol. 11:1282273. doi: 10.3389/fcell.2023.1282273 |
| Author | Edri T, Cohen D, Shabtai Y and Fainsod A |
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© 2023 Edri, Cohen, Shabtai and Fainsod. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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| current | 23:31, 8 June 2024 | | 865 × 565 (90 KB) | Rasbak (talk | contribs) | {{Information |description=FIGURE 7. Reduced RA signaling promotes increased proliferation of neural precursors. Embryos (Xenopus) were injected in one blastomere at the 2-cell stage to affect only half of the embryo. Injections included cyp26a1 mRNA with FITC-dextran or FITC-dextran alone. At the onset of gastrulation, the embryos were sorted based on the injected side and further incubated until late gastrula. Embryos were stained by immunohistochemistry with antibodies against pHH3. The po... |
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