File:Reduced RA signaling induces neural tube closure defects.jpg
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| Description | FIGURE 1. Reduced RA signaling induces neural tube closure defects. Embryos (Xenopus) were treated with DEAB (60 µM), citral (50 µM), or EtOH (0.5% or 1.5% vol/vol) from mid-blastula stages (NF8), and were allowed to develop to neural tube closure stages (NF 19-20). Experimental and control embryos were processed for whole-mount in situ hybridization with markers of the neural plate and notochord, (A–E’) sox3 and chrd.1 and (F–J’) aqp3 and pax8. (A–E), (F–J) Dorsal view of embryos, anterior to the top. (A’-E’), (F’J’) Cross section of the same embryo shown in the panel above, dorsal to the top. Brackets mark NTC defects, black arrowheads mark open neural tubes, blue dotted outline marks the closed neural tube, red dotted outline around the notochord, and green arrowheads mark the pax8 expression. |
| Date | |
| Source | https://www.frontiersin.org/articles/10.3389/fcell.2023.1282273/full Alcohol induces neural tube defects by reducing retinoic acid signaling and promoting neural plate expansion. Front. Cell Dev. Biol. 11:1282273. doi: 10.3389/fcell.2023.1282273 |
| Author | Edri T, Cohen D, Shabtai Y and Fainsod A |
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© 2023 Edri, Cohen, Shabtai and Fainsod. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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| current | 23:25, 8 June 2024 | | 1,065 × 594 (115 KB) | Rasbak (talk | contribs) | {{Information |description=FIGURE 1. Reduced RA signaling induces neural tube closure defects. Embryos (Xenopus) were treated with DEAB (60 µM), citral (50 µM), or EtOH (0.5% or 1.5% vol/vol) from mid-blastula stages (NF8), and were allowed to develop to neural tube closure stages (NF 19-20). Experimental and control embryos were processed for whole-mount in situ hybridization with markers of the neural plate and notochord, (A–E’) sox3 and chrd.1 and (F–J’) aqp3 and pax8. (A–E), (F–J) Dorsal... |
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