File:R-loop promoting factors.jpg

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Captions

Captions

Schematic representation of factors promoting R-loop formation and stabilization

Summary

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Description
English: Negative supercoiling promotes R-loop formation. Topoisomerases inhibit R-loop formation by resolving negative supercoiling. The presence of a nick in the nontemplate strand downstream of a promoter makes DNA reannealing less efficient, which favors nucleation of an R-loop. DNA secondary structures can also stabilize the R-loop structures. G-clusters on the RNA transcript favor R-loop formation. Defects in anti-R-loop factors like RNase H and RNA-DNA helicases also lead to increased R-loop formation.
Date
Source Hegazy, Y. A., Fernando, C. M., & Tran, E. J. (2020). The balancing act of R-loop biology: The good, the bad, and the ugly. Journal of Biological Chemistry, 295(4), 905-913.
Author Hegazy, Y. A., Fernando, C. M., & Tran, E. J.
Other versions Derivative works of this file:  R-loop factors rus.png

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current06:45, 20 June 2021Thumbnail for version as of 06:45, 20 June 20211,280 × 532 (125 KB)Abogomazova (talk | contribs)Uploaded a work by Hegazy, Y. A., Fernando, C. M., & Tran, E. J. from Hegazy, Y. A., Fernando, C. M., & Tran, E. J. (2020). The balancing act of R-loop biology: The good, the bad, and the ugly. Journal of Biological Chemistry, 295(4), 905-913. with UploadWizard

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