File:Proton pump inhibitors structure.svg
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[edit]DescriptionProton pump inhibitors structure.svg |
English: Common structure of proton pump inhibitors. Asterisk indicates stereocenter. Dots indicate lone pair. |
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Source | Own work | ||||
Author | Anypodetos | ||||
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Compound | Substituents | Form | Cysteine binding | pKa | First approval | |||||
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X | R1 | R2 | R3 | R4 | pKaa1 | pKaa1 | year | |||
Omeprazole | CH | OCH3 | CH3 | CH3 | CH3 | Racemic mixture | 813 and 892 | 4.06 | 0.79 | 1989 in USA |
Esomeprazole | CH | OCH3 | CH3 | CH3 | CH3 | (S)-(−)-enantiomer of lansoprazole | 813 and 892 | 4.06 | 0.79 | 2001 in USA |
Lansoprazole | CH | H | CH3 | CH2CF3 | H | Racemic mixture | 813 and 321 | 3.83 | 0.62 | 1991 in Europe |
Dexlansoprazole | CH | H | CH3 | CH2CF3 | H | (R)-(+)-enantiomer of lansoprazole | 813 and 321 | 3.83 | 0.62 | 2009 in USA |
Pantoprazole | CH | OCHF2 | OCH3 | CH3 | H | Racemic mixture | 813 and 822 | 3.83 | 0.11 | 1994 in Germany |
Rabeprazole | CH | H | CH3 | (CH2)3OCH3 | H | Racemic mixture | 813, 892 and 321 | 4.53 | 0.62 | 1999 in USA |
Tenatoprazole | N | OCH3 | CH3 | CH3 | CH3 | Racemic mixture | 813 and 822 | 4.04 | –0.12 | — |
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 12:11, 7 December 2015 | 512 × 227 (10 KB) | Vaccinationist (talk | contribs) | facelifting | |
19:05, 8 February 2012 | 275 × 135 (35 KB) | Anypodetos (talk | contribs) | Mark stereocenter | ||
14:31, 7 February 2012 | 275 × 135 (34 KB) | Anypodetos (talk | contribs) | {{Information |Description ={{en|1=Common structure of {{w|proton pump inhibitor}}s}} |Source ={{own}} |Author =Anypodetos |Date =2012-02-07 |Permission = |other_versions = }} {{BKchem}}{{Inkscape}} [[C |
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