File:Prolactine cell pone.0101403.g002.png
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| Description | Figure 2. Effects of fadrozole on prolactin-positive cells in the pituitary of male rats. a) General disposition of prolactin-positive cells in the gland. PD: pars distalis of pituitary gland. Scale bar: 100 µm. b) Irregular and strongly stained prolactin-positive cells (arrows) in untreated male rats. c) Polygonal and weakly stained prolactin-positive cells (arrows) after 5 doses of fadrozole. Scale bar b, c: 12 µm d) Plot showing the in vivo effects of the 1 or 5 doses of fadrozole on the serum levels of prolactin (ng/mL) (*p<0.01 with respect to untreated and control animals, **p<0.01, with respect to untreated and control animals and p<0.05 with respect to 1 dose of fadrozole-treated animals). Morphometric effect of treatment with fadrozole on cellular (e) or nuclear (f) areas (µm2); in both cases fadrozole induces decreases in size (*p<0.01 with respect to untreated and control animals). |
| Date | |
| Source | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101403 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101403 Local Transformations of Androgens into Estradiol by Aromatase P450 Is Involved in the Regulation of Prolactin and the Proliferation of Pituitary Prolactin-Positive Cells |
| Author | María José García Barrado, Enrique J. Blanco, Marta Carretero Hernández, María Carmen Iglesias Osma, Manuel Carretero, Julio J. Herrero, Deborah Jane Burks, José Carretero |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 22:07, 7 January 2024 | | 3,808 × 3,804 (2.47 MB) | Rasbak (talk | contribs) | {{Information |description=Figure 2. Effects of fadrozole on prolactin-positive cells in the pituitary of male rats. a) General disposition of prolactin-positive cells in the gland. PD: pars distalis of pituitary gland. Scale bar: 100 µm. b) Irregular and strongly stained prolactin-positive cells (arrows) in untreated male rats. c) Polygonal and weakly stained prolactin-positive cells (arrows) after 5 doses of fadrozole. Scale bar b, c: 12 µm d) Plot showing the in vivo effects of the 1 or 5... |
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