File:Pre-replicative complex.JPG
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English: Diagram of the formation of the pre-replicative complex. Mcm 2-7 complex loads onto DNA at replication origins during G1 and unwinds DNA ahead of replicative polymerases. Cdc6 and Cdt1 bring
Mcm complexes to replication origins. CDK/DDK-dependent phosphorylation of pre-replicative proteins leads to replisome assembly and origin firing. Cdc6 and Cdt1 are no longer required and are removed from the nucleus or degraded. Mcms and associated proteins, GINS and Cdc45, unwind DNA to expose template DNA. At this point replisome assembly is completed and replication in initiated. "P" represents phosphorylation. |
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| Source | Own work |
| Author | Azackta1 |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 17:26, 3 May 2013 | | 549 × 490 (29 KB) | Azackta1 (talk | contribs) | User created page with UploadWizard |
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