File:Potenziali meccanismi per la sensibilizzazione ai nocicettori nel COVID-19 grave.jpg
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Potenziali_meccanismi_per_la_sensibilizzazione_ai_nocicettori_nel_COVID-19_grave.jpg (664 × 325 pixels, file size: 116 KB, MIME type: image/jpeg)
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[edit]DescriptionPotenziali meccanismi per la sensibilizzazione ai nocicettori nel COVID-19 grave.jpg |
English: Potential mechanism(s) for nociceptor sensitization in severe COVID-19. SARS-CoV-2 enters lung epithelial cells and resident immune cells through ACE2. In severe COVID-19 cases, IFN production is abrogated allowing the virus to replicate unrestricted. Subsequent increase in viral load further enhances the production of inflammatory mediators and leads to the development of a hyperinflammatory state known as a “cytokine storm.” Cytokines produced in the lower respiratory tract may interact with receptors on sensory nerve endings promoting neurogenic inflammation and nociceptor hypersensitivity. An exaggerated immune response leads to systemic inflammation affecting multiple organs. As such, peripheral blood mononuclear cells (PBMCs) produce potent inflammatory mediators that have known receptors in the sensory neurons and resident immune cells of the DRG, driving nociceptor sensitization. ACE2, angiotensin-converting enzyme 2; DRG, dorsal root ganglia. |
Date | |
Source | (2021). "Neurobiology of SARS-CoV-2 interactions with the peripheral nervous system: implications for COVID-19 and pain". Pain Rep 6 (1): e885. DOI:10.1097/PR9.0000000000000885. PMID 33458558. PMC: 7803673. |
Author | Amelia J. McFarland Department of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, USA |
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current | 12:08, 29 April 2021 | 664 × 325 (116 KB) | OppidumNissenae (talk | contribs) | Uploaded own work with UploadWizard |
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Software used | Adobe Photoshop CS6 (Windows) |
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Date and time of digitizing | 20:17, 25 October 2020 |
File change date and time | 01:33, 24 November 2020 |
Date metadata was last modified | 01:33, 24 November 2020 |
Unique ID of original document | xmp.did:d21f1c8f-2015-470e-8d74-a8d88fa11083 |