File:Platelets are required for the exercise-induced increase in hippocampal neurogenesis in aged mice.webp
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From the study "Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice"
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[edit]DescriptionPlatelets are required for the exercise-induced increase in hippocampal neurogenesis in aged mice.webp |
English: "a Number of proliferating cells in the subgranular zone (SGZ) of 18-month-old C57BL/6J mice (STD n = 10 mice; 28 days RUN n = 9 mice). b Representative image of Ki67+ cells in the dentate gyrus (DG). Scale bars: 100 and 10 μm in box highlighting a cluster of proliferating cells. c Number of DCX+ cells in the DG of 18-month-old C57BL/6J mice (STD n = 10 mice; 28 days RUN n = 9 mice). d Representative image of DCX+ cells in the DG. Scale bars: 100 μm and 15 μm in box highlighting a cluster of DCX+ cells. e Representative image of BrdU/NeuN staining with yellow arrows indicating the same cell in each panel (BrdU—green; NeuN—magenta; DAPI—blue). Scale bar: 10 μm. f Number of BrdU+NeuN+ cells in aged C57BL/6J mice (STD n = 10 mice; 28 days RUN n = 9 mice). g Time course of platelet activation showing a defined peak at 28 days of exercise (n = 10 mice per group). h Individual values of platelet activation on day 28 (n = 10 mice per group). i Experimental design. j Platelet count in exercising and standard-housed mice receiving with control serum (white bars) or antiplatelet serum (grey bars; n = 10 mice in STD groups; n = 13 mice in 28 days RUN control group; n = 14 mice in 28 days RUN platelet-depleted group). k Number of proliferating cells in exercising and standard-housed mice receiving control serum (white bars) or antiplatelet serum (grey bars; n = 10 mice in STD groups; n = 13 mice in 28 days RUN control group; n = 14 mice in 28 days RUN platelet-depleted group). Bars are mean ± SEM. Statistical analysis was performed using unpaired Student’s two-tailed t tests in (a, c, f, h), two-way ANOVA with Sidak post hoc comparison in (g), and one-way ANOVA with Sidak post hoc comparison in (j) and (k). *p < 0.05, **p < 0.01, ****p < 0.0001. Source data are provided as Source Data file." |
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Source | https://www.nature.com/articles/s41467-023-39873-9 |
Author | Authors of the study: Odette Leiter, David Brici, Stephen J. Fletcher, Xuan Ling Hilary Yong, Jocelyn Widagdo, Nicholas Matigian, Adam B. Schroer, Gregor Bieri, Daniel G. Blackmore, Perry F. Bartlett, Victor Anggono, Saul A. Villeda & Tara L. Walker |
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current | 18:05, 17 November 2023 | ![]() | 2,002 × 1,824 (281 KB) | Prototyperspective (talk | contribs) | Uploaded a work by Authors of the study: Odette Leiter, David Brici, Stephen J. Fletcher, Xuan Ling Hilary Yong, Jocelyn Widagdo, Nicholas Matigian, Adam B. Schroer, Gregor Bieri, Daniel G. Blackmore, Perry F. Bartlett, Victor Anggono, Saul A. Villeda & Tara L. Walker from https://www.nature.com/articles/s41467-023-39873-9 with UploadWizard |
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