File:Perturbations of the Müllerian duct (MD) and rete ovarii by deletion of Pax2 andor Pax8 disrupt ovary morphogenesis.jpg
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Fig. 7. Perturbations of the Müllerian duct (MD) and rete ovarii by deletion of Pax2 and/or Pax8 disrupt ovary morphogenesis. (A) Pax2/Pax8 deletion allelic series. Maximum intensity projections from confocal Z-stacks of whole ovary/mesonephros complexes at E17.5 and E18.5, immunostained for KRT8 (cyan) and PAX8 (red). Each sample is representative of the phenotype observed for different combinations of Pax2 and Pax8 deletion alleles. Images in the top row were captured from the dorsal side, and images in the middle, and bottom row from the dorsal side. Images in the bottom row are close-ups of the regions outlined in the middle row. White arrows point to disruptions of the MD. Dashed lines in the bottom row represent the KRT8+ cortical domain of the ovary. (B) The segment of the oviduct is required for ovary encapsulation. Maximum intensity projections from confocal Z-stacks of whole ovary/mesonephros complexes at E17.5, immunostained for KRT8 (cyan) and counterstained with Hoechst nuclear dye (grayscale). The dashed outline represents the ovarian capsule, which is absent in Pax2del/del; Pax8del/+ samples. (C) Only the infundibulum and connecting rete persist in Pax2del/del; Pax8del/+ samples. Maximum intensity projections from confocal Z-stacks of whole ovary/mesonephros complexes at E17.5, immunostained for KRT8 (cyan) and PAX8 (red). Images in the bottom row are close-ups of the regions outlined in the top row: left, rete ovarii; right, infundibulum. (D) The cranial suspensory ligament (CSL) remains tethered to the infundibulum remnant in Pax2del/del; Pax8del/+ and Pax2del/+; Pax8del/del samples. Maximum intensity projections from confocal Z-stacks of whole ovary/mesonephros complexes at E18.5, immunostained for KRT8 (cyan), aSMA (green), and TNC (red). Images in the bottom row are close-ups of the regions outlined in the top row. White arrowheads point to the attachment of the CSL to the infundibulum. Yellow asterisks indicate the location of the infundibulum of the presumptive oviduct for reference. CR, connecting rete; EOR, extraovarian rete; IOR, intraovarian rete; Mv, mesovarium; OA, ovarian artery; OC, ovarian capsule; Ov, ovary; Ovi, oviduct, Ut, uterus. Scale bars, 100 μm. |
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| Source | https://elifesciences.org/articles/81088 Jennifer McKey, Dilara N. Anbarci, Corey Bunce, Alejandra E. Ontiveros, Richard R. Behringer, Blanche Capel Integration of mouse ovary morphogenesis with developmental dynamics of the oviduct, ovarian ligaments, and rete ovarii, bioRxiv 2021.05.21.445181; doi: https://doi.org/10.1101/2021.05.21.445181 |
| Author | Jennifer McKey, Dilara N. Anbarci, Corey Bunce, Alejandra E. Ontiveros, Richard R. Behringer, Blanche Capel |
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| current | 00:06, 6 August 2024 | | 3,658 × 4,409 (3.57 MB) | Rasbak (talk | contribs) | {{Information |description=Fig. 7. Perturbations of the Müllerian duct (MD) and rete ovarii by deletion of Pax2 and/or Pax8 disrupt ovary morphogenesis. (A) Pax2/Pax8 deletion allelic series. Maximum intensity projections from confocal Z-stacks of whole ovary/mesonephros complexes at E17.5 and E18.5, immunostained for KRT8 (cyan) and PAX8 (red). Each sample is representative of the phenotype observed for different combinations of Pax2 and Pax8 deletion alleles. Images in the top row were cap... |
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