File:Pbio.0020429.g001 (14134357941).png
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| Description |
Drosophila Spastin: Sequence Alignment and Gene Map (A) Clustal alignment of complete D. melanogaster and H. sapiens Spastin amino acid sequences and the AAA region of Drosophila Katanin-60. Identical and similar residues are highlighted in dark and light gray, respectively.
(B) Map of the Drosophila spastin gene, including exons (black boxes) and introns, the position of the T32 EP insertion (nucleotide 58 of the 5′ UTR), and the regions deleted by imprecise excision in lines 10-12, 17-7, and 5.75. The 3′ end of the adjacent Rox8 gene is also shown. Arrows indicate direction of transcription.
(C) Unrooted phylogenetic tree generated by the “neighbor” algorithm, showing relationships between the AAA domains of Spastins and their close relatives in human and fly. Dm CG3326 is the counterpart of the human fidgetin/fidlik gene pair, while CG1193 probably encodes a second fly ortholog of human Katanin-60. In the mouse, fidgetin mutations produce inner ear defects that cause head-shaking and circling behaviors (Cox et al. 2000). |
| Date | |
| Source | pbio.0020429.g001 |
| Author | Phylogeny Figures |
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This image was originally posted to Flickr by phylofigures at https://flickr.com/photos/123636286@N02/14134357941. It was reviewed on 19 December 2020 by FlickreviewR 2 and was confirmed to be licensed under the terms of the cc-by-2.0. |
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| current | 13:24, 19 December 2020 | | 4,200 × 4,994 (1.59 MB) | Eyes Roger (talk | contribs) | Transferred from Flickr via #flickr2commons |
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