File:Pathogens-07-00068-g002.webp
From Wikimedia Commons, the free media repository
Jump to navigation
Jump to search
Size of this PNG preview of this WEBP file: 800 × 526 pixels. Other resolutions: 320 × 210 pixels | 640 × 421 pixels | 1,024 × 674 pixels | 1,280 × 842 pixels | 2,560 × 1,684 pixels | 3,346 × 2,201 pixels.
Original file (3,346 × 2,201 pixels, file size: 861 KB, MIME type: image/webp)
File information
Structured data
Captions
Summary
[edit]DescriptionPathogens-07-00068-g002.webp |
English: Replication cycle of Japanese encephalitis virus (JEV). A viral particle binds initially to a target cell through one or more attachment factors on the cell surface (Attachment). Subsequently, the virion interacts with an entry factor(s), which triggers receptor-mediated clathrin-dependent or clathrin-independent endocytosis of the bound virion (Endocytosis). Following internalization, the virion travels through the endosomal maturation pathway until endosomal acidification triggers the low pH-induced activation of the viral E glycoprotein, enabling the fusion between viral and endosomal membranes (Membrane fusion). Upon release of the viral genomic RNA into the cytoplasm (Uncoating), it is translated into two overlapping polyproteins as the result of a −1 ribosomal frameshift event in association with the ER (Translation). The polyproteins are co- and post-translationally cleaved to generate the mature viral proteins that are essential for RNA replication and virion assembly. The genomic RNA is replicated in the replication complex within a structurally rearranged ER-derived membrane vesicles (RNA replication). Viral assembly proceeds with the concomitant interaction of viral RNA with the three structural proteins (C, prM, and E), promoting the budding of immature particles into the lumen of the ER (Assembly). The immature virions, containing heterodimers of prM and E, are then transported through the trans-Golgi network, where prM is cleaved to form mature virions containing homodimers of M and E (Maturation). Finally, both partially and completely mature virions are released into the extracellular milieu (Release). |
Date | |
Source | https://www.mdpi.com/2076-0817/7/3/68/htm |
Author | Sang-Im Yun and Young-Min Lee |
Licensing
[edit]This file is licensed under the Creative Commons Attribution 4.0 International license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
File history
Click on a date/time to view the file as it appeared at that time.
Date/Time | Thumbnail | Dimensions | User | Comment | |
---|---|---|---|---|---|
current | 08:55, 16 November 2020 | 3,346 × 2,201 (861 KB) | Guest2625 (talk | contribs) | Uploaded a work by Sang-Im Yun and Young-Min Lee from https://www.mdpi.com/2076-0817/7/3/68/htm with UploadWizard |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.
File usage on other wikis
The following other wikis use this file:
- Usage on en.wikipedia.org
- Usage on fr.wikipedia.org