File:Paroxysmalnocturnalhemoglobinuria.png
From Wikimedia Commons, the free media repository
Jump to navigation
Jump to search
Paroxysmalnocturnalhemoglobinuria.png (749 × 399 pixels, file size: 215 KB, MIME type: image/png)
File information
Structured data
Captions
Captions
Paroxysmal nocturnal hemoglobinuria
Summary
[edit]DescriptionParoxysmalnocturnalhemoglobinuria.png |
English: Hemolysis mechanism of paroxysmal nocturnal hemoglobinuria (PNH) via the complement system [4]. (a) Normal RBC possesses CD55 and CD59 which are glycosylphosphatidylinositol (GPI)-anchored self-protective complement regulatory factors. CD55 is a widely expressed membrane protein that accelerates the decay of C3 convertases. CD59 is the major inhibitor of terminal complement, which blocks the generation of the membrane attack complex (MAC). (b) Intravascular hemolysis of PNH RBC through C3 convertase and MAC. (c) Extravascular hemolysis of PNH RBC via macrophage. Eculizumab inhibits the complement activation by compensating CD59. *PNH, a life-threatening disease characterized by destruction of RBC by complement system; eculizumab, a monoclonal antibody complement inhibitor which is highly effective for PNH; C3 con, C3 convertase; C5b-8, complex of C5b, C6, C7, and C8 proteins; C3dg, a fragment of C3 protein, which is ligand of integrin (CR3) on macrophage; iC3b, inactivated C3b; Hb, hemoglobin; CR3, complementary 3. |
Date | |
Source | https://www.intechopen.com/chapters/65464 |
Author | Insu Kim, Gyudo Lee and Dae Sung Yoon |
Licensing
[edit]![w:en:Creative Commons](https://upload.wikimedia.org/wikipedia/commons/thumb/7/79/CC_some_rights_reserved.svg/90px-CC_some_rights_reserved.svg.png)
![attribution](https://upload.wikimedia.org/wikipedia/commons/thumb/1/11/Cc-by_new_white.svg/24px-Cc-by_new_white.svg.png)
This file is licensed under the Creative Commons Attribution 3.0 Unported license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
File history
Click on a date/time to view the file as it appeared at that time.
Date/Time | Thumbnail | Dimensions | User | Comment | |
---|---|---|---|---|---|
current | 00:47, 29 January 2024 | ![]() | 749 × 399 (215 KB) | Ozzie10aaaa (talk | contribs) | Uploaded a work by Insu Kim, Gyudo Lee and Dae Sung Yoon from https://www.intechopen.com/chapters/65464 with UploadWizard |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.
Metadata
This file contains additional information such as Exif metadata which may have been added by the digital camera, scanner, or software program used to create or digitize it. If the file has been modified from its original state, some details such as the timestamp may not fully reflect those of the original file. The timestamp is only as accurate as the clock in the camera, and it may be completely wrong.
PNG file comment |
|
---|---|
Horizontal resolution | 59.05 dpc |
Vertical resolution | 59.05 dpc |
Structured data
Items portrayed in this file
depicts
Hidden category: