File:PNN.png
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English: A. Perineuronal nets are made of chondroitin sulfate proteoglycans (CSPG). Here, the CSPGs neuroscan, veriscan, brevican, and aggrecan are noncovalently bonded to hyaluron. Other associations occur between other CSPGs through tenascin (T, triangles). Tenascin, in turn, binds to CS glycosaminoglycans (red lines) as well as cell surface CSPGs. Phosphacan can also bind to cell surface receptors such as NCAM. B. Application of chondroitinase ABC (ChABC) degrades all the CS glycosaminoglycans (red lines) as well as hyaluronan (pink line), causing major disruptions in the structure of the perineuronal net. These disruptions may allow axons to penetrate the vacated space and allow restoration of neuronal plasticity. |
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| Source | Own work |
| Author | Bbari3 |
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I, the copyright holder of this work, release this work into the public domain. This applies worldwide. In some countries this may not be legally possible; if so: I grant anyone the right to use this work for any purpose, without any conditions, unless such conditions are required by law. |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 16:01, 1 December 2010 | | 973 × 1,076 (114 KB) | Bbari3 (talk | contribs) | |
| 15:58, 1 December 2010 |  | 973 × 1,076 (114 KB) | Bbari3 (talk | contribs) | {{Information |Description={{en|1=A. Perineuronal nets are made of chondroitin sulfate proteoglycans (CSPG). Here, the CSPGs neuroscan, veriscan, brevican, and aggrecan are noncovalently bonded to hyaluron. Other associations occur between other CSPGs thr |
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