File:Nramp.gif

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Nramp.gif (600 × 538 pixels, file size: 12.96 MB, MIME type: image/gif, looped, 200 frames, 20 s)

Captions

Captions

Internal rearrangements during DraNramp conformational changes

Summary

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Description
English: Natural resistance-associated resistance macrophage proteins (NRAMPs) are a diverse clade of metal ion transporters throughout all clades of life. This gif, created by Rachelle Gaudet's lab at Harvard University, shows a morph of the protein homolog from the bacterium D. radiodurans through three separate conformation states captured via x-ray crystallography: the outward-open state, the inward-occluded state, and the inward-open state. This mechanism of conformation switching occurs upon metal binding and is how the protein is able to transport metals through the membrane and into the cytoplasm.
Date
Source Bozzi, A. T., Zimanyi, C. M., Nicoludis, J. M., Lee, B. K., Zhang, C. H., & Gaudet, R. (2019). Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter. Elife, 8, e41124.
Author Aaron Bozzi, Christina Zimanyi annd Rachelle Gaudet

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Date/TimeThumbnailDimensionsUserComment
current21:26, 17 February 2020Thumbnail for version as of 21:26, 17 February 2020600 × 538 (12.96 MB)Samuel.P. Berry (talk | contribs)User created page with UploadWizard

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