File:Nicolau syndrome (livedoid dermatitis) Macroscopic view, microscopic view and particles analysis of a representative cutaneous lesion obtained from the same patient.png

English: Macroscopic view, microscopic view and particles analysis of a representative cutaneous lesion obtained from the same patient.A: necrotic livedo-like dermatitis lesion from the lower left leg. The red arrow represents the injection site. B: macrophages easily distinguished by CD68 immunolabelling among a perivascular inflammatory infiltrate exhibited few refringent material (red arrows). C: transmission electron microscopy, we have observed non organic very dense particles, without epoxy permeation but with either a round shape compatible with silica or with a laminated aspect compatible with silicate. D: High magnification of figure 1C inlay by transmission electron microscopy and energy-dispersive x-ray spectroscopy spectra analysis. Particles primarily identified as very dense and non organic contain silica (Si).