File:Negative Node from Mastectomy Specimen; Cytokeratin Immunostain with Expression of Chromogen by Mast Cells (6959258321).jpg

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Lobular carcinomas are so cytologically bland that they present devilish problems with false-negative biopsies. However, false-positives can also be a problem, as shown in this node, which could be misinterpreted as keratin-positive cells in the medullary sinus, thus a false-positive for isolated tumor cells (ITC). In fact, these are benign mast cells that have converted the chromogen in the absence of any antibody-antigen or avidin-biotin reaction.

Pathological and histological images courtesy of Ed Uthman at flickr.
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Negative Node from Mastectomy Specimen; Cytokeratin Immunostain with Expression of Chromogen by Mast Cells

Author Ed Uthman from Houston, TX, USA

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This image, originally posted to Flickr, was reviewed on 11 December 2013 by the administrator or reviewer File Upload Bot (Magnus Manske), who confirmed that it was available on Flickr under the stated license on that date.

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current12:10, 11 December 2013Thumbnail for version as of 12:10, 11 December 20131,426 × 1,425 (529 KB)File Upload Bot (Magnus Manske) (talk | contribs)Transferred from Flickr by User:CFCF

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