File:Multiple mechanisms can lead to EMT-associated population heterogeneity.png
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| Description | Figure 2. Multiple mechanisms can lead to EMT-associated population heterogeneity. (A) During cell division, noise can lead to asymmetric partitioning of molecules among daughter cells. This may lead to the daughter cell exhibiting a phenotype different from that of the parent cell. Consequently, the fractions of cells exhibiting different phenotypes can change over time. (B) Cell–cell communication (left) mediated by, for example Notch-Delta-Jagged signaling, can lead to cells spontaneously acquiring “signal sender”, “signal receiver”, and “signal sender/receiver” phenotypes in a population (right: different colors correspond to different cell phenotypes). (C) The kinetics of gene regulation can vary in different cells due to stochasticity in kinetic parameters. Thus, each parameter can exhibit some variation in its value in a given isogenic population (left: each curve denotes the distribution of values of an individual parameter in a given population). This heterogeneity can lead to cells in the population acquiring different phenotypes in response to the same external cues (right: heatmap indicates the emergence of various phenotypes. Each row represents a cell and each column represents the expression level of one gene. Red color represents relatively high gene expression and blue color represents relatively low gene expression with white indicating intermediate expression levels). |
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| Source | https://www.mdpi.com/2077-0383/8/5/725 Quantifying Cancer Epithelial-Mesenchymal Plasticity and its Association with Stemness and Immune Response. J. Clin. Med. 2019, 8, 725. https://doi.org/10.3390/jcm8050725 |
| Author | Jia, D.; Li, X.; Bocci, F.; Tripathi, S.; Deng, Y.; Jolly, M.K.; Onuchic, J.N.; Levine, H. |
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© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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| current | 22:47, 29 May 2024 | | 2,004 × 2,164 (2.01 MB) | Rasbak (talk | contribs) | {{Information |description=Figure 2. Multiple mechanisms can lead to EMT-associated population heterogeneity. (A) During cell division, noise can lead to asymmetric partitioning of molecules among daughter cells. This may lead to the daughter cell exhibiting a phenotype different from that of the parent cell. Consequently, the fractions of cells exhibiting different phenotypes can change over time. (B) Cell–cell communication (left) mediated by, for example Notch-Delta-Jagged signaling, can l... |
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