File:MicroRNAs are integral to transcription networks in ESCs..jpg

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English: The circuit map that integrates transcription regulation and microRNA functions is constructed based on existing data. A core set of TFs regulates themselves, as well as the expression of microRNAs. MicroRNAs, whose expressions are positively regulated, are frequently associated with self-renewal, whereas those negatively regulated in ESCs are associated with differentiation. In addition, microRNAs feedback into the transcription circuitry through post-transcriptional modulation of their TF targets, controlling their levels and activity. Several other microRNAs appear to have roles in either self-renewal or differentiation, but their upstream regulators have yet been identified.
Date Published September 15, 2008.
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StemBook Figure 5 MicroRNAs are integral to transcription networks in ESCs.

  • Tam, W.-L. and Lim, B., Genome-wide transcription factor localization and function in stem cells (September 15, 2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.19.1, http://www.stembook.org.
Author Tam, W.-L. and Lim, B., Genome-wide transcription factor localization and function in stem cells (September 15, 2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.19.1, http://www.stembook.org.
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