File:Metanephric nephron formation..jpg
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Metanephric_nephron_formation..jpg (600 × 155 pixels, file size: 49 KB, MIME type: image/jpeg)
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DescriptionMetanephric nephron formation..jpg |
English: Nephrons arise from pretubular aggregates, a subpopulation of the cap mesenchyme, in response to Wnt9b. Early molecular markers of pretubular aggregates are Pax8, Fgf8, and Wnt4. Wnt4 maintains the expression of these genes, induces Lhx1, and converts the pretubular aggregate into an epithelial vesicle. The renal vesicle displays polarized expression of the Brn1/Pou3f3 transcription factor gene in presumptive distal nephron precursors. Growth of the renal vesicle leads to the stereotypical formation of comma- and S-shaped bodies. Notch2 signaling is necessary for the specification of proximal nephron fates (podocytes and proximal tubule). Angioblasts invade the proximal cleft of the S-shaped body and contribute to the glomerular capillary. The distal portion of the S-shaped body fuses with the collecting duct. |
Date | Published January 15, 2009. |
Source |
[1] Direct
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Author | Davidson, A.J., Mouse kidney development (January 15, 2009), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.34.1, http://www.stembook.org. |
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This file is licensed under the Creative Commons Attribution 3.0 Unported license.
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 18:48, 5 April 2013 | 600 × 155 (49 KB) | Smallbot (talk | contribs) | Uploading CC-BY images from the the StemBook http://www.stembook.org/ 59/173 |
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