File:Metabolic pathways of cyproterone acetate in humans.png
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[edit]DescriptionMetabolic pathways of cyproterone acetate in humans.png |
English: Metabolic pathways of cyproterone acetate in humans.
"CPA is almost completely metabolized via the cytochrome P450 isoenzyme CYP3A4, and its main metabolite is 15β-OHCPA." Source: (April 2018). "Current understanding on pharmacokinetics, clinical efficacy and safety of progestins for treating pain associated to endometriosis". Expert Opin Drug Metab Toxicol 14 (4): 399–415. DOI:10.1080/17425255.2018.1461840. PMID 29617576. "The major metabolic steps are hydroxylation and deacetylation, while the D4-double bond is preserved. The antiandrogenic activity of 15β-hydroxy-CPA is similar to that of CPA, but the progestogenic efficacy is only 10% of that of CPA [17]." Source: Kuhl H (2011). "Pharmacology of Progestogens" (PDF). J Reproduktionsmed Endokrinol 8 (1): 157–177. "[CPA is metabolised via various degradation pathways, including via hydroxylation and conjugation steps. The major metabolite in serum is 15β-hydroxy-CPA.]" Source: (2015). "Hirsutismus – Medikamentöse Therapie Gemeinsame Stellungnahme der Deutschen Gesellschaft für Gynäkologische Endokrinologie und Fortpflanzungsmedizin e.V. und des Berufsverbands der Frauenärzte e.V.". Journal für Reproduktionsmedizin und Endokrinologie 12 (3): 102-149. ISSN 1810-2107. |
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Author | Medgirl131 |
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