File:Mechanisms of VSG switching2.png
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[edit]DescriptionMechanisms of VSG switching2.png |
English: Mechanisms of VSG switching in T. brucei:
A. Structure of the expression site including the expression site associated genes (ESAG), 70 base pair repeat up-stream sequence, expressed VSG gene, and the telomere B. Mechanism of array VSG conversion: A silent VSG is copied from a subtelomeric VSG array into an ES, where it replaces the active VSG. C. Telomeric VSG conversion: A telomeric VSG (including 70 bp repeat sequence upstream and telomere downstream) replaces the active VSG in the ES D. Segmental VSG conversion: Sequence is copied from multiple inactive VSG genes and combined into a novel mosaic VSG that occupies the ES E. Transcriptional VSG switching: A non-recombination based mechanism that activates a new (previously silent) ES, while inactivating the previously active ES. |
Date | |
Source | Adapted from: PLoS Biol. 2008 Jul 29;6(7):e185. |
Author | Chris Stockdale, Michal R. Swiderski, J. David Barry, Richard McCulloch |
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