File:LAP-TGFb1 homodimer.png

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Original file (2,100 × 2,100 pixels, file size: 1.31 MB, MIME type: image/png)

Captions

Captions

Homodimer of TGFb1 and its prodomain.

Summary

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Description
English: TGFb forms a homodimer where the actual TGFb growth factor (green colors) is surrounded by a cage formed by the prodomain, called LAP (magenta colors). The two growth factors of the homodimer (light and dark green) are hold together by several disulfid bridges in the central cysteine knot. The cage of the two LAP proteins (birght and dark magenta) is hold together at its uppest part by a disulfid bridge. The helices in the lowest part are coupled to other proteins (not shown) by additional disulfid bridges. Based on PDB ID 3VI4.
Deutsch: TGFb bildet einen Homodimer, bei dem der eigentliche TGFb Wachstumsfaktor (grüne Farben) von einem Käfig umgeben ist, der durch die LAP genannten Prodomänen (pinkene Farben) gebildet wird. Die beiden Wachstumsfaktoren des Homodimers (helles und dunkles grün) werden durch mehrere Disulfidbrücken im zentralen Cysteinknoten zusammengehalten. Der Käfig aus zwei LAP Proteinen (helles und dunkles pink) wird durch eine Disulfidbrücke an seiner obersten Stelle im Bild zusammengehalten. Die Helices am unteren Bildrand sind über Disulfidbrücken an weitere Proteine (nicht gezeigt) gebunden. Basierend auf PDB ID 3VI4.
Date
Source Own work
Author Mitchzw

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current17:35, 1 May 2020Thumbnail for version as of 17:35, 1 May 20202,100 × 2,100 (1.31 MB)Mitchzw (talk | contribs)Uploaded own work with UploadWizard

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