File:Journal.ppat.1005890.g001.A.jpg

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Captions

Schematic of the life cycle of the L-A virus of S. cerevisiae.

Summary

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Description
English: Schematic of the lifecycle of the L-A virus of S. cerevisiae. Starting at the bottom of the figure, new viral positive sense single-stranded RNA (+ssRNA) is synthesized within the L-A virus capsid and extruded into the cytoplasm. The enzymatic activity of the viral Gag protein “steals” cap structures from host mRNAs and conjugates them to viral +ssRNAs. The capped viral +ssRNA is used as a template for translation and any remaining uncapped +ssRNA is encapsidated to form new viral particles by interaction with the L-A polymerase protein. Packaged +ssRNA is used as a template during negative strand synthesis to produce viral genomic dsRNA.
Date
Source https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005890
Author Paul A. Rowley, Brandon Ho, Sarah Bushong, Arlen Johnson, and Sara L. Sawyer

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