File:Joining of single-ended double strand breaks could lead to rearrangements.png

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Joining of single-ended double strand breaks could lead to rearrangements

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Description
English: (Left panel): A single-ended DSB generated by replication stress is normally repaired by SCE in a conservative way. Rearrangements occur when a single-ended DSB is joined to another single-ended DSB, which is likely to be distal.

(Middle panel): The annealing of few nucleotides at the extremity of the single ended DSB with another broken fork activates the MMBIR (microhomology-mediated break-induced replication) mechanism. MMBIR coupled to several switches in fork templates leads to complex rearrangements and has been proposed to be a mechanism that originates chromotripsis.

(Right panel): The end-joining (EJ) by C-NHEJ or A-EJ of the single ended DSB with another single-ended DSB lead to dicentric chromosome formation.[1]
Date
Source https://doi.org/10.3390/genes6020267
Author Camille Gelot, Indiana Magdalou, and Bernard S. Lopez

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This file is licensed under the Creative Commons Attribution 4.0 International license.
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