File:Interstate medical journal (1917) (14780639001).jpg

Identifier: interstatemedica2419unse (find matches)
Title: Interstate medical journal
Year: 1917 (1910s)
Authors:
Subjects: Medicine
Publisher: St. Louis, : Interstate Medical Journal
Contributing Library: The College of Physicians of Philadelphia Historical Medical Library
Digitizing Sponsor: The College of Physicians of Philadelphia and the National Endowment for the Humanities

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mitations are eventually transcended and that certain of theirfunctions are necessarily transferred to other tissues, the muscles and pan-creas probably taking over a certain number of them. One not infrequentlysees extraordinary changes in the heart due to replacement of the muscle 1112 INTERSTATE MEDICAL JOURNAL substance by fat, inflammatory tissue, tumor cells and the like. For example,a case recently came to autopsy at Bellevue Hospital in which there was almostcomplete replacement of the left ventricle by lymphosarcoma cells. I havein mind, also, a case of syphilitic cirrhosis of the lungs in which enormousquantities of pulmonary tissue were destroyed, relatively few air spaces beingdetected either by the naked eye or microscopically. In the case of the brainit is equally astonishing to observe to what an enormous extent its sub-stance may be destroyed by slowly growing tumors, collections of fluid inthe ventricles, etc. Extensive destructive lesions in the kidney are frequently
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Polycystic degeneration of kidney. observed in the form of chronic interstitial nephritis with great reductionin volume, and experimental ablation of the kidney, if done slowly, may becarried out to a remarkable extent without producing death of the animal. In the autopsy room at Bellevue Hospital we have just had occasion toinvestigate the body of a woman, 41 years of age, both of whose kidneyspresented the changes usually described under the title of congenital poly-cystic degeneration. The naked eye and microscopic changes were such asto reveal almost complete destruction of the secreting substance. Three theories have been advanced to account for the pathogenesis ofthe polycystic kidney, the inflammatory, the neoplasmic and the embryonal.The inflammatory theory is accredited to Virchow, who suggested that the Symmers: Pathological Anatomy 1113 condition is due to intrauterine papillitis resulting in obliteration of the con-voluted tubules and the formation of retention cysts. This

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