File:Induction of thrombotic thrombocytopenia during COVID-19.png

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Italiano: A) Il Sars-CoV-2 induce il rilascio del fattore piastrinico 4 (PF4) da parte delle piastrine attivate e di proteoglicani polianionici (PG) da cellule endoteliali (ad esempio syndecan, endocan)

B) I complessi B di PF4 e PG espongono epitopi immunogenici PF4 che attivano Linfociti B extrafollicolari secernenti autoanticorpi PF4

C) Gli autoanticorpi PF4 legano complessi di PF4 e PG su piastrine e cellule endoteliali e stimolare le loro attività procoagulanti. Promuove anche il cross-linking di FC recettori IIA apoptosi e la clearance delle piastrine rivestite di anticorpi.
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https://www.preprints.org/manuscript/202104.0255/v1

Goldman, M. Autoimmune Thrombotic Thrombocytopathy Associated with COVID-19 Infection or Vaccination: Learning from Heparin-induced Thrombocytopenia. Preprints 2021, 2021040255
Author Goldman, M.

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current12:01, 12 April 2021Thumbnail for version as of 12:01, 12 April 2021554 × 310 (77 KB)OppidumNissenae (talk | contribs)Uploaded a work by Goldman, M. from https://www.preprints.org/manuscript/202104.0255/v1 Goldman, M. Autoimmune Thrombotic Thrombocytopathy Associated with COVID-19 Infection or Vaccination: Learning from Heparin-induced Thrombocytopenia. Preprints 2021, 2021040255 with UploadWizard

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