File:Induction of thrombotic thrombocytopenia during COVID-19.png
Induction_of_thrombotic_thrombocytopenia_during_COVID-19.png (554 × 310 pixels, file size: 77 KB, MIME type: image/png)
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Summary
[edit]DescriptionInduction of thrombotic thrombocytopenia during COVID-19.png |
Italiano: A) Il Sars-CoV-2 induce il rilascio del fattore piastrinico 4 (PF4) da parte delle piastrine attivate e di proteoglicani polianionici (PG) da cellule endoteliali (ad esempio syndecan, endocan)
B) I complessi B di PF4 e PG espongono epitopi immunogenici PF4 che attivano Linfociti B extrafollicolari secernenti autoanticorpi PF4 C) Gli autoanticorpi PF4 legano complessi di PF4 e PG su piastrine e cellule endoteliali e stimolare le loro attività procoagulanti. Promuove anche il cross-linking di FC recettori IIA apoptosi e la clearance delle piastrine rivestite di anticorpi. |
Date | |
Source | Goldman, M. Autoimmune Thrombotic Thrombocytopathy Associated with COVID-19 Infection or Vaccination: Learning from Heparin-induced Thrombocytopenia. Preprints 2021, 2021040255 |
Author | Goldman, M. |
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current | 12:01, 12 April 2021 | 554 × 310 (77 KB) | OppidumNissenae (talk | contribs) | Uploaded a work by Goldman, M. from https://www.preprints.org/manuscript/202104.0255/v1 Goldman, M. Autoimmune Thrombotic Thrombocytopathy Associated with COVID-19 Infection or Vaccination: Learning from Heparin-induced Thrombocytopenia. Preprints 2021, 2021040255 with UploadWizard |
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