File:Hypothetical contribution of EMT to the pathophysiology of pSS.png
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| Description | Figure 4. Hypothetical contribution of EMT to the pathophysiology of pSS (primary Sjögren’s Syndrome). Upon stimuli such as inflammation (IL-6, IL-17 and IL-22), several signaling pathways become activated in normal SGEC present in salivary glands. These EMT signaling pathways culminate with the production of several EMT-related TFs such as SNAI1, ZEB1 and ETS1 leading to the acquisition of mesenchymal features. This results in salivary gland fibrosis with the appearance of spindle-shaped morphology of SGEC together with the expression of mesenchymal markers such as vimentin, podoplanin, MMP9 and several collagen types. Abbreviations: ADAMTS: A Disintegrin And Metalloproteinase with Thrombospondin Motifs; COL3A1: collagen type III Alpha 1 chain; EMT: epithelial-mesenchymal transition; ERK: extracellular signal–regulated kinase; IL: interleukin; iSGEC: immortalized SGEC; MMPs: matrix metalloproteases; SGEC: salivary gland epithelial cells; SMAD: homolog of the Drosophila protein, mothers against decapentaplegic (Mad) and the Caenorhabditis elegans protein Sma; SNAI1: Snail family transcriptional repressor; SS: Sjögren’s syndrome; TFs: transcription factors; TGF-β: transforming growth factor-β; ZEB2: zinc finger e-box binding homeobox 2. Created with Biorender.com (accessed on 20 August 2023). |
| Date | |
| Source | https://www.mdpi.com/1422-0067/24/19/14481 Involvement of Epithelial-Mesenchymal Transition (EMT) in Autoimmune Diseases. Int. J. Mol. Sci. 2023, 24, 14481. https://doi.org/10.3390/ijms241914481 |
| Author | Sarrand, J.; Soyfoo, M.S. |
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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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| current | 00:48, 17 May 2024 | | 3,169 × 1,958 (313 KB) | Rasbak (talk | contribs) | {{Information |description=Figure 4. Hypothetical contribution of EMT to the pathophysiology of pSS (primary Sjögren’s Syndrome). Upon stimuli such as inflammation (IL-6, IL-17 and IL-22), several signaling pathways become activated in normal SGEC present in salivary glands. These EMT signaling pathways culminate with the production of several EMT-related TFs such as SNAI1, ZEB1 and ETS1 leading to the acquisition of mesenchymal features. This results in salivary gland fibrosis with the appea... |
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